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徐国良(中国科学院院士)

徐国良,男,上海生命科学研究院研究员,德国马普分子遗传学研究所博士后,2002年入选中科院“百人计划”,并获得“国家杰出青年科学基金”,2015年12月7日,当选中国科学院院士。

1981.9-1985.7:浙江大学生物系,学士;1985.9-1989.8:中国科学院遗传所,硕士;1989.9-1993.3:德国马普分子遗传学研究所,博士;1993.3-1994.7:德国马普分子遗传学研究所,博士后;1994.8-1995.9:新加坡国立大学生命科学中心,实验室主任;1995.1-2000.3:美国哥伦比亚大学遗传发育系,博士后;2000.4-2001.7:美国哥伦比亚大学医学系,Associate Research Scientist;2001.8-至今任中国科学院与德国马普学会国际合作青年科学家小组组长。2015年12月7日,当选中国科学院院士 [2]

DNA甲基化与发育调控

Jing-Yu Li, Min-Tie Pu, Ryutaro Hirasawa, Bin-Zhong Li, Yan-Nv Huang, Rong Zeng, Nai-He Jing, Taiping Chen, En Li, Hiroyuki Sasaki and Xu G.-L. (2007) Synergistic Function of DNA Methyltransferases Dnmt3a and Dnmt3b in the Methylation of Oct4 and Nanog. Mol. Cell. Biol., 27, 8748-8759.

Ya-Qiang Li, Ping-Zhu Zhou, Xiu-Dan Zheng, Colum P. Walsh and Xu G.-L. (2007) Association of Dnmt3a and Thymine DNA Glycosylase Links DNA Methylation with Base Excision Repair. Nucleic Acids Research, 35, 390-400.

Xie Z.-H., Huang Y.-N., Chen Z.-X., Riggs A.D., Ding J.-P., Gowher H., Jeltsch A., Sasaki H., Hata K. and Xu G.-L*. (2006) Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L. Human Molecular Genetics 15, 1375-1385.

Yuki O., Feng Q., Lin Y., Jiang Q., Li Y., Coffield V.M., Su L., Xu G.-L* and Zhang Y*. (2005) hDOT1L Links Histone Methylation to Leukemogenesis. Cell 121,167-178 (Erratum in Cell 121, 809; * corresponding authors).

Ge, Y-Z, Pu, M.-T., Gowher, H., Ding J.-P., Jeltsch, A. and Xu G-L. (2004) Chromatin-targeting of de novo DNA methyltransferases by PWWP domain. J. Biol. Chem. 279, 25447-25454.

Cheng J.C., Weisenberger D.J., Gonzales F.A., Liang G., Xu G.-L., Hu Y.-G., Marquez V.E. and Jones P. A. (2004) Continuous Zebularine treatment effectively sustains demethylation in human bladder cancer cells. Mol. Cell. Biol. 24, 1270-1278.

Bourc´his D., Xu, G.-L., C.-S. Lin, B. Bollman and T. H. Bestor. (2001) Dnmt3L and the establishment of maternal genomic imprints. Science 294, 2536-2539.

Xu, G.-L., T. H. Bestor, D. Bourc´his, C.L. Hsieh, N. Tommerup, M., Bugge, X., Qu, J. J. Russo and E. Viegas-Péquignot. (1999) Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature 402, 187-191.

Xu, G.-L. and T. H. Bestor. (1997) Cytosine methylation targeted to predetermined sequences. Nature Genetics 17, 376-378.

Chuang, L.S.H., Ian H.-I., Hoh H.-H., Ng H.-H., Xu G.-L. and Li B.F.L. (1997) Human DNA-(Cytosine-5) methyltransferase PCNA complex as a target for p21 WAF1. Science 277, 1996-2000.

2015年7月31日,入选中国科学院院士增选初步候选人名单。 [3]

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